Continuing the Medcrux MCQ Series – Part 3 for INICET November 2025 and NEET PG 2026 preparation. Practice these 10 high-yield questions with explanations to strengthen your concepts efficiently.
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| Sharpen your concepts for NEET PG & INICET 2025 with Medcrux MCQs – Part 3 |
👉 Missed earlier parts? Check them here: Part 1 MCQs • Part 2 MCQs
🔹 MCQs with Explanations
1) In rabies, Negri bodies are most commonly found in which of the following locations?
A) Basal ganglia
B) Purkinje cells of the cerebellum
C) Motor neurons of the spinal cord
D) Thalamus
✅ Correct Answer: B) Purkinje cells of the cerebellum
👉 Negri bodies in rabies are usually found as eosinophilic, cytoplasmic inclusions in the pyramidal neurons of the hippocampus and Purkinje cells of the cerebellum, sites usually devoid of inflammation.
2) Which of the following medications is most commonly associated with cornea verticillata?
A) Leflunomide
B) Primaquine
C) Chloroquine
D) Apraclonidine
✅ Correct Answer: C) Chloroquine
👉 Vortex keratopathy aka cornea verticillata are fine golden-brown opacities in the lower corneal epithelium.
👉 Causes include:
👉 Amiodarone
👉 Chloroquine and hydroxychloroquine
👉 Fabry disease
3) A 21-year-old male has a fascination with fire and enjoys setting multiple fires in his neighbourhood. Which substance abuse is most commonly linked to this behaviour?
A) Cannabis
B) Heroin
C) Alcohol
D) Cocaine
✅ Correct Answer: C) Alcohol
👉 The patient's history is suggestive of pyromania.
👉 The substance abuse most commonly associated with pyromania is alcohol.
👉 Pyromania is the deliberate setting of fires on more than one occasion.
4) Which of the following interventions is preferred for a 3rd to 5th rib fracture not responding to analgesics?
A) Cervical block
B) Thoracic epidural block
C) Supraclavicular block
D) Lumbar epidural block
✅ Correct Answer: B) Thoracic epidural block
👉 Thoracic epidural block will be given to reduce rib fracture pain.
👉 Cervical block: Neck and upper shoulders.
👉 Supraclavicular block: Upper limb by blocking the brachial plexus.
👉 Lumbar epidural block: Pelvis and lower extremities.
5) Which part of the hypothalamus regulates body temperature?
A) Lateral hypothalamus
B) Paraventricular nucleus
C) Anterior and posterior hypothalamus
D) Suprachiasmatic nucleus
✅ Correct Answer: C) Anterior and posterior hypothalamus
👉 Anterior hypothalamus: controls reflexes activated by warmth (like cutaneous vasodilation, sweating).
👉 Posterior hypothalamus: controls reflexes activated by cold (like cutaneous vasoconstriction, shivering).
6) What is the most common cause of chronic kidney disease?
A) Hypertensive nephropathy
B) Glomerulonephritis
C) Diabetic nephropathy
D) ADPKD
✅ Correct Answer: C) Diabetic nephropathy
👉 The leading causes of CKD in decreasing order of frequency are as follows:
👉 Diabetic nephropathy
👉 Glomerulonephritis
👉 Hypertension-associated CKD
👉 ADPKD (Adult autosomal dominant polycystic kidney disease)
7) You are visiting a family for a pediatric assessment. When you arrive, you see a young boy riding a tricycle towards the stairway. He dismounts, ascends the stairs using alternate feet, and makes his way to his play area. Once there, you notice he has built a tower with 9 blocks and can draw a circle using the colored markers you provided. Based on these developmental achievements, what is the likely age of the child?
A) 12 months
B) 18 months
C) 2 years
D) 3 years
✅ Correct Answer: D) 3 years
👉 At around 3 years old, children reach key developmental milestones across various areas.
👉 In gross motor skills, they can ride a tricycle and walk up stairs using alternate feet.
👉 Fine motor abilities allow them to build a tower of 9 blocks and draw simple shapes, like a circle.
👉 Socially, they begin to share toys, show interest in counting, and can identify 1-2 colors.
👉 Language skills develop as they frequently ask questions and know their full name, reflecting their growing curiosity and self-awareness.
👉 These milestones highlight the rapid growth typical of early childhood.
8) A 22-year-old woman presents to the emergency department after accidentally swallowing 10 tablets of a Phenobarbital. Given her condition, which component of the electron transport chain (ETC) is likely inhibited by this substance?
A) Succinate-Fe
B) Cytochrome I-II
C) Complex I to Q
D) Complex IV
✅ Correct Answer: C) Complex I to Q
👉 Phenobarbital, a barbiturate, inhibits Complex I (NADH-Q oxidoreductase) in the electron transport chain.
👉 This complex is responsible for oxidizing NADH and reducing coenzyme Q.
👉 By blocking this step, Phenobarbital prevents electron transfer from NADH to coenzyme Q, leading to reduced ATP production and decreased oxygen consumption.
👉 Thus, the correct answer is C. Complex I to Q.
9) Which is a selective endothelin receptor A antagonist used in the management of pulmonary artery hypertension?
A) Bosentan
B) Ambrisentan
C) Tezosentan
D) Macitentan
✅ Correct Answer: B) Ambrisentan
👉 Ambrisentan is a targeted antagonist of the endothelin receptor A (ET-A) that is utilized in treating pulmonary artery hypertension (PAH).
👉 A. Bosentan: Non-selective endothelin receptor antagonist
👉 C. Tezosentan prevents binding of endothelin-1 to its receptors, in particular endothelin-B receptors, which have been reported to be responsible for endothelin-1 clearance.
👉 D. Macitentan is an endothelin receptor antagonist (ERA) that binds to endothelin A and B receptors (EA and EB). It prevents ET-1 from binding to ETA and ETB receptors, which are found on smooth muscle cells.
10) A 45-year-old farmer presents with symptoms including a high fever accompanied by chills, retro-orbital pain, and redness in the eyes. Upon examination, significant tenderness in the calves is noted. Laboratory tests reveal low potassium levels and a decrease in neutrophil count. What is the most probable diagnosis?
A) Malaria
B) Dengue
C) Chikungunya
D) Leptospirosis
✅ Correct Answer: D) Leptospirosis
👉 The most likely diagnosis is leptospirosis, characterized by high fever, chills, retro-orbital pain, conjunctival suffusion, severe calf tenderness, and lab findings of hypokalemia and neutropenia.
👉 This zoonotic infection, caused by Leptospira spirochetes, often presents with flu-like symptoms, myalgia (especially in the calves), and can lead to severe complications like Weil's syndrome.
🔹 Clinical Pearls 💡
- 👉 Rabies: Negri bodies — hippocampus (pyramidal neurons) & Purkinje cells of cerebellum.
- 👉 Vortex keratopathy (cornea verticillata) → think amiodarone, chloroquine/hydroxychloroquine, or Fabry disease.
- 👉 Thoracic epidural analgesia is excellent for multiple rib fractures with refractory pain.
🔹 Final Notes
That’s it for Part 3 of the Medcrux MCQ Series.
Keep practicing – MCQs with explanations are the fastest way to prepare smartly for your exams.
👉 Looking for more resources?
Check out Part 1 of Medcrux MCQs, Part 2, or my other blog 👉 Mediflips 📚💉
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